Clinical pathways in chronic lymphocytic leukemia: Challenges and solutions
نویسندگان
چکیده
منابع مشابه
Clinical pathways in chronic lymphocytic leukemia: Challenges and solutions.
Progress in prognosticating and treating patients with chronic lymphocytic leukemia (CLL) has led to deeper remissions, longer disease-free intervals, and better overall survival (OS) [1]. Many factors have led to these incremental improvements. First, understanding the different risk categories in CLL allowed better treatment refinement [2]. Second, incorporating anti-CD20 antibodies (specific...
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Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
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Introduction: CLL is one of the most common leukemias, which is categorized by the accumulation of mature CD5+ B-lymphocytes in the peripheral blood, bone marrow, and secondary lymphoid organs. In this study, the status of rs6449182 polymorphism of the CD38 gene and its association with clinical and laboratory parameters of CLL patients was evaluated. Methods: Genomic DNA extraction was perfor...
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IMPORTANCE The most common leukemia is chronic lymphocytic leukemia (CLL). Every year, there are 15 000 new diagnoses and 5000 CLL deaths in the United States. Although therapeutic choices were once limited, treatment of this disease has vastly improved in the last decade. OBJECTIVE Evidence-based review of the diagnosis, staging, and treatment of CLL. EVIDENCE REVIEW PubMed, Cochrane Libra...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2016
ISSN: 0361-8609
DOI: 10.1002/ajh.24589